Functional Neuroanatomy of Pain
Pain is defined by the International Association for the Study of Pain (IASP)
as an unpleasant sensory and emotional experience associated with actual or
potential tissue damage, or described in terms of such damage or both. Pain is an unpleasant but very important biological signal for danger. Nociception is
necessary for survival and maintaining the integrity of the organism in a potentially
hostile environment (Hunt and Mantyh 2001; Scholz andWoolf 2002). Pain is not a monolithic entity. It is both a sensory experience and a perceptual metaphor for damage (i.e., mechanically, by infection), and it is activated by noxious stimuli that act on a complex pain sensory apparatus.
However, sustained or chronic pain can result in secondary symptoms (anxiety,
depression), and in a marked decrease of the quality of life. This spontaneous
and exaggerated pain no longer has a protective role, but pain becomes a ruining
disease itself (Basbaum 1999; Dworkin and Johnson 1999; Woolf and Mannion
1999; Dworkin et al. 2000; Hunt and Mantyh 2001; Scholz andWoolf 2002). If pain
becomes the pathology, typically via damage and dysfunction of the peripheral
and central nervous system, it is termed “neuropathic pain.”
Here, we present an updated review of the functional anatomy of normal and neuropathic pain.Book details:Author:K.G. Usunoff · A. Popratiloff ·,O. Schmitt · A.WreePublisher: Springer; 1 edition (November 14, 2005)Pages:126Size:5,91 MBFormat:PDFDownloadmirror
Manual on the Management, Maintenance And Use of Blood Cold Chain Equipment
Blood transfusion is an essential therapeutic intervention. We all may
need blood in an emergency, and some of us need regular transfusions.
The purpose of a transfusion is to provide the blood component(s) that
will improve the physiological status of the patient. Various blood components can be harvested from a single donation of whole blood. Most blood banks are able to separate red cells and plasma components. Others
are able to prepare components such as platelet concentrates and cryoprecipitate.
All these components, prepared by centrifugation, are often referred to as ‘wet or labile products’. Other plasma products, generally referred to as plasma derivatives, can be harvested from plasma by a pharmaceutical process called plasma fractionation, which renders their properties stable.Book details:Author:Department of Essential Health Technologies,World Health OrganizationPublisher:World Health OrganizationPages:106Size:5,420 MBFormat:PDFDownload
The Clinical Use of Blood Handbook
This pocket handbook summarizes key information from the module to
provide a quick reference when an urgent decision on transfusion is required.
It is important to follow national guidelines on clinical blood use if they
differ in any way from the guidance contained in the module and handbook.You may therefore find it useful to add your own notes on national guidelines or your own experience in prescribing transfusion.
The Clinical Use of Blood has been prepared by an international team of clinical and blood transfusion specialists and has been extensively reviewed by relevant WHO departments and by Critical Readers from a range of clinical disciplines from all six of the WHO regions. The content reflects the knowledge and experience of the contributors and reviewers.However, since the evidence for effective clinical practice is constantly
evolving, you are encouraged to consult up-to-date sources of information
such as the Cochrane Library, the National Library of Medicine database
and the WHO Reproductive Health Library.Book details:
Author: World Health Organization ,Blood Transfusion Safety ,GENEVA
Publisher: world health organization
Pages:221
Size: 701KB
Format:PDF Download
Suspected Anaphylactic Reactions associated with anaesthesia
In 1990, the Association of Anaesthetists of Great Britain and Ireland(AAGBI) published its first report on suspected anaphylactic reactionsassociated with anaesthesia.In 1995, a second edition was published jointlywith the British Society for Allergy and Clinical Immunology (BSACI) in anattempt to help members of both societies with advice about theinvestigation and subsequent management of patients suspected of havingsuffered an anaphylactic reaction associated with anaesthesia.The third working party was established to give particular attention to theresults of recent reports such as that of the Resuscitation Council dated1999, and on the value of investigations and their availability to anaesthetistsin Great Britain and Ireland.The incidence of anaphylactic reactions and the associatedmorbidity/mortality in the UK is still unclear. It is the view of the workingparty that the incidence of suspected anaphylactic reactions duringanaesthesia is low but the number of cases may be increasing.2.4There remains uncertainty about which laboratory investigations should beundertaken following a reaction as well as their interpretation andsignificance. The role of the anaesthetist in the investigations has been acause for concern.Booklet details:Author:working groupPublisher:The Association of Anaesthetists of Great Britain and Irelandand British Society for Allergy and Clinical ImmunologyPages:24Size:268 KBFormat:pdfDownload
Relied on for 20 years by resident and practicing anesthesiologists and CRNAs, this best-selling pocket reference is now in its Sixth Edition. In easy-to-scan outline format, it provides current, comprehensive, concise, consistent, and clinically relevant guidelines for anesthesia procedures throughout the preoperative, intraoperative, and postoperative periods. Each chapter is written by a Massachusetts General Hospital resident with a faculty mentor, and the entire book has been reviewed, updated, and field-tested by the anesthesia staff. This edition includes new information on muscle relaxants, opioids, minimally invasive abdominal surgery, pediatrics, end-of-life issues, and latex allergies, plus a comprehensive, alphabetical drug appendix.Book details:Author:William E Hurford, Michael T Bailin,J. Kenneth Davison,Kenneth L Haspel, Carl E RosowPublisher:Massachusetts General Hospital, Boston.Size:2,897 MBFormat: PDBDownloadpassword:DrWaelRelated Books:The Massachusetts General Hospital Handbook of Pain Management
